BROADCASTS.com

Published: Aug. 23, 2015, 12:12 p.m.

Hosts:\xa0Vincent Racaniello, Dickson Despommier,\xa0Alan Dove,\xa0Rich Condit, and Kathy Spindler

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The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation\xa0of dengue virus by recoding the genome.

\nLinks for this episode\n

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• Paula Pitha-Rowe (Balt Sun)
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• Novel poxvirus (CID)
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• H1N1 and gain-of-function debate (mBio)
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• Recoding dengue virus genome (PNAS)
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• Attenuation by dinucleotide frequency change (PNAS)
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• Codon pair and dinucleotide bias not distinguished (PNAS)
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• Codon pair deoptimization\xa0artefact of CG/UA change (eLife)
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• Can engineering subdue viral vaccine reversion? (Virus Evol)
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• Attenuation by a thousand cuts (NEJM)
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• Image credit
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• Letters read\xa0on TWiV 351
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\nWeekly Science Picks\n

Alan - Genetic roulette
Rich\xa0- The Huntington
Kathy - Simulated vomiting machine (video)
Dickson - Last Cassini Saturn flyby
Vincent\xa0- Decaying Still Life (YouTube)

\nListener Pick of the Week\n

Ken\xa0-\xa0Cave meterology (Times, Nature)

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