TWiV 1134: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Merck\u2019s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.
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Links for this episode- Clesrovimab,\xa0RSV preventative monoclonal antibody\xa0for infants (Merck)
- COVID-19\xa0national trend\xa0(CDC)
- COVID-19\xa0deaths\xa0(CDC)
- Characterizing SARS-CoV-2\xa0reinfections\xa0and long COVID (Communications Medicine)
- Cost-effectiveness of COVID\xa0rapid diagnostic tests\xa0(PLoS Medicine)
- NVX-CoV2373\xa0against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID)
- Combined Protection of\xa0Vaccination and Nirmatrelvir-Ritonavir\xa0Against Hospitalization(CID)
- Pemgarda\xa0infusion center\xa0locator\xa0(Pemgarda)
- Respiratory virus\xa0guidance\xa0(CDC)
- Early phase\xa0of SARS-CoV-2 infection (COVID.gov)
- NIH\xa0COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines\xa0for treatment and management (ID Society)
- Drug interaction\xa0checker\xa0(University of Liverpool)
- Molnupiravir\xa0safety\xa0and efficacy (JMV)
- Convalescent plasma recommendation for\xa0immunocompromised\xa0(ID Society)
- What do when your\xa0heathcare provider\xa0is infected with SARS-CoV-2 (CDC)
- Managing healthcare staffing\xa0shortages\xa0(CDC)
- Steroids,dexamethasone\xa0at the right time (OFID)
- Anticoagulation\xa0guidelines (hematology.org)
- Cognitive trajectories\xa0in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging)
- Contribute to our\xa0Floating Doctors\xa0fundraiser
- Letters read\xa0on TWiV 1134
- Dr. Griffin\u2019s COVID treatment summary (pdf)
- Timestamps by\xa0Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv