TWiV 1132: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr, Daniel Griffin reviews President Biden\u2019s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.
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Links for this episode- President Biden has COVID (CNN,\xa0USA Today)
- COVID-19\xa0national trend\xa0(CDC)
- COVID-19\xa0deaths\xa0(CDC)
- Post\u2013acute sequelae of COVID after infection during pregnancy (OB & Gyn)
- Oral nirmatrelvir\u2013ritonavir as\xa0postexposure prophylaxis for Covid-19\xa0(NEJM)
- Pemgarda\xa0infusion center\xa0locator\xa0(Pemgarda)
- Unable to access pemgarda, gotta\xa0call Daniel\xa0(microbeTV)
- CDC Quarantine\xa0guidelines (CDC)
- Early phase\xa0of SARs-CoV-2 infection (COVID.gov)
- NIH\xa0COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines\xa0for treatment and management (ID Society)
- Drug interaction\xa0checker\xa0(University of Liverpool)
- Combined treatment\xa0of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis)
- Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy)
- Comparative\xa0effectiveness of combination therapy\xa0with nirmatrelvir\u2013ritonavir and remdesivir versus monotherapy (Lancet)
- Molnupiravir\xa0safety\xa0and efficacy (JMV)
- Convalescent plasma recommendation for\xa0immunocompromised\xa0(ID Society)
- Isolation\xa0guidance (CDC)
- Managing healthcare staffing\xa0shortages\xa0(CDC)
- Steroids,\xa0dexamethasone\xa0at the right time (OFID)
- Anticoagulation\xa0guidelines (hematology.org)
- Long COVID is defined\xa0(National Academies)
- Long COVID: the\xa0ANSWERS! (longcovidtheanswers.com)
- The FACTS:\xa0post COVID-19=long COVID? (WHO)
- The\xa0BASICS\xa0of long COVID-19 (CDC)
- Postacute sequelae of SARS-CoV-2 infection in the\xa0pre-delta, delta, and omicron eras\xa0(NEJM)
- Long Covid\xa0risk has dropped over time\xa0but remains substantial (CNN)
- Efficacy of antivirals, corticosteroids, and mAbs as\xa0acute COVID treatments in reducing the incidence of long COVID\xa0(Clin Micro Inf)
- Diet and the gut microbiome: implications for health and disease (Nat Rev Micro)
- Contribute to our\xa0Floating Doctors\xa0fundraiser
- Letters read\xa0on TWiV 1132
- Dr. Griffin\u2019s COVID treatment summary (pdf)
- Timestamps by\xa0Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv