TWiV 1126: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high\xa0HLA-DQA2\xa0expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.
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Links for this episode- CDC ACIP for\xa0RSV\xa0(CDC)
- This respiratory virus season everyone\xa0age 75 and older\xa0receive the RSV vaccine (CDC Newsroom)
- Revised\xa0RSV vaccine recommendations (CIDRAP)
- COVID-19\xa0national trend\xa0(CDC)
- COVID-19\xa0deaths\xa0(CDC)
- Local and systemic\xa0response dynamics to SARS-CoV-2 infection (Nature)
- Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience)
- Cannabis, tobacco\u2026smoking in general NOT good\xa0for preventing COVID-19 (JAMA Network OPEN)
- Do older versions of the COVID-19 vaccine\xa0still provide\xa0any protection (JAMA Internal Medicine)
- Where\xa0to get pemgarda (Pemgarda)
- CDC Quarantine\xa0guidelines (CDC)
- Early phase\xa0of SARs-CoV-2 infection (COVID.gov)
- NIH\xa0COVID-19 treatment guidelines (NIH)
- Infectious Disease Society guidelines\xa0for treatment and management (ID Society)
- Adjuvant\xa0statin therapy\xa0reduces SARS-CoV-2 mortality (American Journal of Medicine)
- Nirmatrelvir and ritonavir beyond 5 days of symptom onset\xa0improved\xa0the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease)
- Molnupiravir\xa0safety\xa0and efficacy (JMV)
- Convalescent plasma recommendation for\xa0immunocompromised\xa0(ID Society)
- What do when your\xa0heathcare provider\xa0is infected with SARS-CoV-2 (CDC)
- Managing healthcare staffing\xa0shortages\xa0(CDC)
- Steroids,\xa0dexamethasone\xa0at the right time (OFID)
- Anticoagulation\xa0guidelines (hematology.org)
- Faecal microbtiota transplantation\xa0cures\xa0sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology)
- Long COVID defined by patient\xa0phenotype\xa0(CIDRAP)
- Three\xa0distinct symptom-based\xa0post-COVID condition phenotypes (JID)
- Contribute to our\xa0Floating Doctors\xa0fundraiser
- Letters read\xa0on TWiV 1126
- Dr. Griffin\u2019s COVID treatment summary (pdf)
- Timestamps by\xa0Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv