TWiV 1103: Jason 'Spike' McLellan
Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.
Hosts: Vincent Racaniello\xa0and\xa0Rich Condit
Guest:\xa0Jason McLellan
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Links for this episode- MicrobeTV Discord Server
- MicrobeTV store at\xa0Cafepress
- Become a member of ASV (asv.org)
- The New City\xa0by Dickson Despommier
- Prefusion-stabilized\xa0SARS-CoV-2 spikes (Science)
- Structure-based\xa0vaccine design\xa0(Curr Opin Immunol)
- Prefusion-stabilized SARS-CoV-2\xa0S2-only antigen\xa0(Nat Comm)
- Stabilized\xa0coronavirus spike stem\xa0elicits broadly protective antibody (Cell Rep)
- Timestamps by\xa0Jolene. Thanks!
Intro music is by\xa0Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv