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Hosts:\xa0Vincent Racaniello,\xa0Dickson Despommier,\xa0and\xa0Daniel Griffin

The\xa0TWiPniks\xa0solve the case of the Man With AIDS, and explore how secretion of extracellular vesicles\xa0influences the social motility of Trypanosoma brucei.

Become a\xa0patron\xa0of TWiP.

• T. brucei exosomes and social motility (PLoS Path)
• Image credit
• Parasites Without Borders
• Letters read\xa0on TWiP 130

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Back in Peru. 24 yo female seen in ER, lives in rural area outside of big city, adobe house in highlands, thatched roof, dirt floor, 3000 meters. Quite ill with skin lesion for 48 h. 2 days before was pulling on pjs, felt sharp sudden pain in right upper leg. Next day found small living creature in pajamas, inguinal region. Developed red lesion, enlarged, developed black central dot. Then begins vomiting, comes to hospital. No fever, breathing fast 20, hr 70, bp 160/10, on exam see in right inguinal region an enlarging, necrotic area 1-2 cm, starting to look sick. Whites at 26000, left shift, 200 platelets, eosinophils 4%, bilirubin 3.5, creatinine 4.9 (going into renal failure, not making much urine). Hematocrit 14, BUN 59.7, CPK 227, RBCs and leukocytes in urine. No health problems, no surgeries, first interaction with health system. No toxic habit. Brings in the small creature!

Send your case diagnosis, questions and comments to\xa0twip@microbe.tv

Music by\xa0Ronald Jenkees