TWiP 124: RPAing with the tryps
Hosts:\xa0Vincent Racaniello,\xa0Dickson Despommier,\xa0and\xa0Daniel Griffin
The\xa0prolific podcast-shedding Hosts\xa0solve the case of the Global Health Intern\xa0with a snakelike lesion on her foot, and reveal the role of a single-stranded DNA binding protein in differentiation\xa0of trypanosomes.
Become a\xa0patron\xa0of TWiP.
Links for this episode:- RPA protein and\xa0differentiation\xa0of\xa0T. cruzi\xa0(PLoS NTD)
- Image credit
- Letters read\xa0on TWiP 124
28 yo male from referral hospital near thai-burma border. Fever and chills 2 days, feels poorly, small amount of dark urine. Severe shaking chills, 1x per day, no rash. No diarrhea, difficulty breathing. Seen by local health care volunteer, went to hospital then tertiary hospital in Bangkok. Exposure history to pigs, dogs, insects, etc. Involved in timber industry and farming, sleeping out at night with no cover, clothes and sandals. No meds. Not married, family lives with him. Family is fine. Sleep in dwelling but no screens. No toxic habits, HIV negative, sexually active but not brothels. High fever, low bp, rapid heart rate, breathing rapidly, scleral icterus, dry mucus membranes, neck supple, lungs clear. 2/6 systolic murmur. Abdomen soft but tender, enlarged liver and spleen. Many cuts, bruises, bug bites. Labs: low platelets, low hematocrit, low glucose. Blood smear: abnormal, 5-10% infected RBCs with multiple band forms.\xa0
Send your case diagnosis, questions and comments to\xa0twip@microbe.tv