BROADCASTS.com

Hosts:\xa0Vincent Racaniello, Dickson Despommier, and\xa0Daniel Griffin

The TWiP triumvirate solve the case of the\xa0Thai Woman with Facial Swelling, and explain how Th17 T cells protect against the intracellular parasite\xa0Trypanosoma cruzi.

Become a\xa0patron\xa0of TWiP.

• Th17 cells protect\xa0against\xa0Trypanosoma cruzi\xa0(PLoS Path)
• Plasticity\xa0of helper CD4+ cells (Science)
• Image credit
• Letters read\xa0on TWiP 120

This episode is sponsored by\xa0CuriosityStream,\xa0a subscription streaming service that offers over 1,400 documentaries and non\xadfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at\xa0curiositystream.com/microbe\xa0and use the promo code MICROBE.

A 48 yo man from Mali comes to hospital ER in Washington Heights in NY with profuse watery diarrhea. Born in Mali, came to US at 18, working in US as long haul truck driver for 30 y, frequently visits Mali, recently to attend his father\u2019s funeral. Got symptoms one week after return (was there for 3 weeks). 3 liters diarrhea/day. No past med/surg history, not seen doctor in long time. No allergies. Unknown what father died of, Mother in Mali is ok. No medications. Some alcohol, marijuana use. Does report that has exposure to professional female sex workers, no condoms. Temp of 39 C, bp down 80/40, heart over 110, rapid breathing high 20s, cachectic. Wasted. Fungating lesion perianally. Undergoes HIV testing, clade B. T cells <100.\xa0

Send your case diagnosis, questions and comments to\xa0twip@microbe.tv