TWiP 108: B1 cells and Leishmania, insider traitors
Hosts:\xa0Vincent Racaniello,\xa0Dickson Despommier, and Daniel Griffin
\nThe case of the Man\xa0from Assam is solved, and phagocytosis of Leishmania by B-1 cells\xa0is\xa0brought to you by\xa0the\xa0Three Twipeteers\xa0on this episode of TWiP.
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\nLinks for this episode:\n- \n
- Kalazar detect\xa0(pdf) \n
- Phagocytosis\xa0of\xa0Leishmania\xa0promastigotes by B-1 cells (Parasite Immunol) \n
- Image credit \n
- Letters read\xa0on TWiP 108 \n
This episode is sponsored by\xa0ASM Agar Art Contest\xa0and\xa0ASM Microbe 2016
\nCase study for TWiP\xa0108\nTodays case is a\xa026 yo male longhaul truck driver from northern tiger country of India. Comes into hospital at end of rainy season with 6 days of fever, chills, muscle aches, small loose stools, vomiting, trouble breathing, cough, decreased urine output. Lives in mud hut with coconut leaf roof. No one else in family \xa0is sick (wife, two children). Significant animal and insect exposure (dogs, cows, monkeys). Got sick after coming home from a trip up north. No significant medical probs, no surgery. Really sick. Pain everywhere. Occasionally drinks palm wine. Some yellowing of eyes. Has lost a little weight. Ketonic breath. Exam: 39 fever, bp 100/71, 126 heart rate, 24 resp rate. Looks distressed, not fully sharp. Nothing focal on lung exam. Belly tender, esp upper right, spleen enlarged. Liver is tender but not enlarged. Some labs: bun elevated 102, creatinine elevated, Hg decreased 11, platelets 9000 (down), white count 10.3 no eosinophils. LDH 8000 AST/ALT normal, bilirubin 21. Never been this sick.
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