TWiP 104: La maladie du sommeil
Hosts:\xa0Vincent Racaniello,\xa0Dickson Despommier, and Daniel Griffin
\nGuest: Michael Libman
\nMichael returns to help the TWiP trio solve the case of the Delusional African Expatriate, and discuss the association of natural and induced antibodies in mice with differential\xa0susceptibility to secondary cystic echinococcosis.
\nLinks for this episode:\n- \n
- T. brucei life cycle (pdf) \n
- Natural and induced antibodies in echinococcosis (Immunobiol) \n
- The collaborative cross \n
- Letters read\xa0on TWiP\xa0104 \n
This week's case involves a\xa0young man\xa0in his thirties, admitted in hospital in Anchorage AK in early June. Chief complaint, severe muscle pain and tenderness. Usually healthy guy, 1 week ago had bad case of diarrhea with belly pain and vomiting, lasted a full week. Now has fever. Concerned because wife now is having diarrhea. Unremarkable history, unknown family history. HIV negative. All childhood vaccinations. Does not eat raw meat. No meds, does seasonal work, social drinker. Came back from successful hunt, got a black bear. Dressed in field, cooked at home really well. Wife also ate bear meat. Bear meat is in freezer. No vegetables. Also eats salmon which he caught the previous season, then frozen. Drinks water from the stream when he hunts. Physical exam: hot, 38.5, bp 115/75, pulse 105, breathing comfortably. Anxious, swelling around both eyes. Sclera not noted. Labs: WBC elevated 14,000, 30% eosinophils; chemistries fine; muscle enzymes LDH, CK elevated.
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\nSend your questions and comments to\xa0twip@microbe.tv