Turning a cancer cells greed against itself

Published: April 16, 2021, 5:03 p.m.

How can we use the exceptional greed of cancer cells against them? \n\nThey gobble up all the resources in their local environment, spread to another area, and then gobble up more resources. \n\nThales Papagiannakopoulos, PhD, explains that there\u2019s a cost to that. A cancer cell takes a lot of fuel, but it produces a lot of waste. It has a few tricks for getting rid of that waste, such as taking advantage of antioxidants in our diet, but Dr. Papagiannakopoulos and his team are exploring some innovative approaches to this problem.\n\nIn this conversation, Dr. Papagiannakopoulos takes us through cancer metabolism and the implications of ACS-funded cancer research that has moved into clinical trials.\n\n3:30 - Thales Papagiannakopoulos, PhD, is Associate Professor in the Department of Pathology at NYU Grossman School of Medicine\n\n4:26 \u2013What does metabolism do for normal cells? How does the metabolism of immune cells help them fight off infections?\n\n9:03 \u2013 How does a cell\u2019s need for energy change as it becomes a cancer cell?\n\n11:06 \u2013 Cancer cells as factories \n\n15:02 \u2013 How a higher metabolism can also damage cancer cells\u2026\n\n17:01 \u2013 How cancer cells accumulate and clear out free radicals\n\n23:50 \u2013 How cancer cells take advantage of antioxidants in our diet \n\n26:44 \u2013 Exciting therapeutic implications resulting from these insights\n\n32:17 \u2013 How ACS funding helped move his research into clinical trials