Lipids! Their role in glioblastoma and potential as a therapeutic target
Lipids are fat molecules normally found in the membranes that surround each cell in the body. They also play a critical role in cellular communication. Ray Blind, PhD, and his lab have been investigating how a particular lipid turns cancer genes on and off in glioblastoma. In this interview he talks about how this happens as well as the very exciting therapeutic potential of his work. \n\nRay Blind, PhD, is Assistant Professor of Medicine at Vanderbilt University Medical Center.\n\n2:57 \u2013 Lipids? What are lipids? Why are they important?\n\n9:40 \u2013 What does the cutting edge of science tell us what it\u2019s like in the nucleus? \n\n15:28 \u2013 A nuclear lipid the Blind Lab studies interacts with chromatin. Why is that interaction important?\n\n18:24 \u2013 How this nuclear lipid might be especially important in glioblastoma \n\n21:39 \u2013 \u201cYou know the lipid is there, you know it has a role in cancer, we also assume that it has a role in normal cell development\u2014is there a way to block it and not impact normal development or function? What would be the therapeutic translation?\u201d\n\n23:58 \u2013 \u201cWell, this is what we\u2019re really most excited about\u2026\u201d \u2013 chemical genetics, and the therapeutic potential of ongoing work in his lab\n\n30:29 \u2013 The impact of ACS funding on his lab and on the direction of his research\n\n34:01 \u2013 A message he\u2019d like to share with cancer patients