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Published: Dec. 14, 2023, 3 a.m.

This is part two of our three part series where we explore the intricate ways genetics intersect with ADHD. In our previous episode, we discussed how genetics influence ADHD, laying the foundation for today's discussion. If you missed last week, make sure and go back and listen to that episode, because it lays the foundation for today\u2019s.\xa0

If you have ever wondered about MTHFR or other genes that affect ADHD and ASD, tune in to today\u2019s episode to learn more. MTHFR is often regarded as the poster child of ADHD and autism, but there are many other genes that also play a role.\xa0

Here is the chart mentioned in the episode:\xa0

\xa0

677CC

2 normal

677CT

One variant

677TT

Two variants

1298AA

2 normal

100%

66%

25%

1298AC

One variant

83%

48%

\xa0

1298CC

Two variants

61%

\xa0 \xa0

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Key Takeaways:

[2:45] What is Methylation?

[4:15] Examples of What Methylation Does In the Body

[6:23] Genes that Affect Methylation

[6:55] MTHFR

[13:20] SHMT1

[16:46] MTRR

[18:29] MTR

[20:48] FUT2

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Memorable Moments:

\u201cIt\u2019s not just about one gene mutation. It\u2019s about looking at the overall picture.\u201d

\u201dIf you have a MTHFR genetic mutation, it impairs the body\u2019s ability to break down that folic acid, which may lead to a buildup of folic acid in the body. Excess folic acid can contribute to a range of health issues, including cognitive decline, mood and behavioral disorders, and potentially even increase the growth rate of cancer cells.\u201d

\u201cSo the take away that you need to write down right now is\xa0 - If you have a mutation in the MTHFR, you should not eat packaged goods that are fortified with synthetic folic acid.\u201d

\u201dMost people look at MTHFR in isolation and you really need to look at the methylation as a whole if you want to get a better picture of how the body is functioning. There are also other genes that play a massive role in methylation.\u201d

\u201dSo the takeaway here is - If you have have a SHMT1 mutation, using Folinic acid instead of Methyl-folate is the better way to go.\u201d

\u201cUnderstanding these genes can really help you tailor your approach to managing ADHD. It's like having a personalized roadmap to help you navigate through the ups and downs of ADHD.\u201d

\u201cThe more you know about your or your child's genes, the better choices you can make.\u201d

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