Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.11.379008v1?rss=1 Authors: Buck, S. A., Steinkellner, T., Aslanoglou, D., Villeneuve, M., Bhatte, S. H., Childers, V. C., Rubin, S. A., De Miranda, B. R., O'Leary, E. I., Neureiter, E. G., Fogle, K. J., Palladino, M. J., Logan, R. W., Glausier, J. R., Fish, K. N., Lewis, D. A., Greenamyre, J. T., Bonci, A., McCabe, B. D., Cheetham, C. E., Hnasko, T. S., Freyberg, Z. Abstract: Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of dopamine (DA) neurons, with males at greater risk than females. We found that vesicular glutamate transporter (VGLUT) expression mediates vulnerability to age-related DA neurodegeneration in a sex-dependent manner, providing a new mechanism for sex differences in DA neuron vulnerability. These findings lay the groundwork for novel therapeutic strategies to boost neuronal resilience throughout aging. Copy rights belong to original authors. Visit the link for more info