Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury

Published: Oct. 21, 2020, 5:01 a.m.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.21.346635v1?rss=1 Authors: Pluchino, S., Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J. Abstract: Innate immune responses following spinal cord injury (SCI) participate in early secondary pathogenesis and wound healing events. Here, we used time-resolved scRNAseq to map transcriptional profiles of SC tissue-resident and infiltrating myeloid cells post-SCI. Our work identifies a novel subpopulation of Fabp5+ inflammatory myeloid cells, comprising both resident and infiltrating cells and displaying a delayed cytotoxic profile at the lesion epicentre, which may serve as a target for future therapeutics. Copy rights belong to original authors. Visit the link for more info