Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.27.118695v1?rss=1 Authors: Gottlieb, A., Doniger, G. M., Hussein, Y., Noy, S., Plotnik, M. Abstract: BackgroundFear of flying (FoF) is an anxiety disorder classified as a phobia. Its prevalence is estimated at 10-40% in the industrialized world, and it is accompanied by severe economic, social, vocational and emotional consequences. In recent years, virtual reality-based exposure therapy (VRET) for FoF has been introduced. One such FoF-VRET is offered as a paid clinical service at the Center of Advanced Technologies in Rehabilitation (CATR), Sheba Medical Center, Israel. Positive long-term efficacy of FoF-VRET has been found in several studies. However, these studies are limited by relatively small, non-representative samples and a lack of comparative pre/post functional efficacy outcome measures. MethodsTo address these limitations, we conducted a retrospective survey of self-referred individuals treated with FoF-VRET at CATR over the previous four years. The aim of the present study was to evaluate the efficacy of our FoF-VRET in this representative real-world sample. Of 274 individuals who received the treatment, 214 met inclusion/criteria, and 103 agreed to participate. The survey focused mainly on collecting information regarding flight activity before and after treatment. The primary outcome measures were: (1) number of flights per month (FpM); (2) number of flight hours per month (FHpM). For each participant, these outcomes were computed for the post-treatment period ([≥]6 months after FoF-VRET) and the corresponding pre-treatment period. ResultsFpM (mean{+/-}SD) increased from .05{+/-}.07 to .16{+/-}.07 flights (p<.0001). FHpM rose from.22{+/-}.41 to .80{+/-}.86 hours per month (p<.0001). ConclusionsThese results are indicative of FoF-VRET treatment efficacy. Future studies should evaluate long-term maintenance of the treatment effect and thus identify the optimal frequency for delivery of periodic booster treatments. Copy rights belong to original authors. Visit the link for more info