Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.11.089383v1?rss=1 Authors: Jiang, X., Howard, J. H., Rebeck, G. W., Turner, R. S. Abstract: Spatial inhibition of return (IOR) refers to the phenomenon by which individuals are slower to respond to stimuli appearing at a previously cued location compared to un-cued locations. Here we provide evidence supporting that spatial IOR is mildly impaired in individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), and the impairment is readily detectable using a novel double cue paradigm. Furthermore, reduced spatial IOR in high-risk healthy older individuals is associated with reduced memory and other neurocognitive task performance, suggesting that the novel double cue spatial IOR paradigm may be useful in detecting MCI and early AD. Copy rights belong to original authors. Visit the link for more info