Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.31.126573v1?rss=1 Authors: Nariai, H., Hussain, S. A., Bernardo, D., Motoi, H., Sonoda, M., Kuroda, N., Asano, E., Nguyen, J., Elashoff, D., Sankar, R., Bragin, A., Staba, R. J., Wu, J. Y. Abstract: Objective: To investigate the diagnostic utility of high frequency oscillations (HFOs) via scalp electroencephalogram (EEG) in infantile spasms. Methods: We retrospectively analyzed interictal slow-wave sleep EEGs sampled at 2,000 Hz recorded from 30 consecutive patients who were suspected of having infantile spasms. We measured the rate of HFOs (80-500 Hz) and the strength of the cross-frequency coupling between HFOs and slow-wave activity (SWA) at 3-4 Hz and 0.5-1 Hz as quantified with modulation indices (MIs). Results: Twenty-three patients (77%) exhibited active spasms during the overnight EEG recording. Although the HFOs were detected in all children, increased HFO rate and MIs correlated with the presence of active spasms (p < 0.001 by HFO rate; p < 0.01 by MIs at 3-4 Hz; p = 0.02 by MIs at 0.5-1 Hz). The presence of active spasms was predicted by the logistic regression models incorporating HFO-related metrics (AUC: 0.80-0.98) better than that incorporating hypsarrhythmia (AUC: 0.61). The predictive performance of the best model remained favorable (87.5% accuracy) after a cross-validation procedure. Conclusions: Increased rate of HFOs and coupling between HFOs and SWA are associated with active epileptic spasms. Significance: Scalp-recorded HFOs may serve as an objective EEG biomarker for active epileptic spasms. Copy rights belong to original authors. Visit the link for more info