Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.04.076844v1?rss=1 Authors: Funk, A., Labilloy, G., Reigle, J., Alnafisah, R., Heaven, M., Roberts, R., Shamsaei, B., Greis, K., Meller, J., McCullumsmith, R. Abstract: The overarching goal of this exploratory study is to link subcellular microdomain specific protein-protein interactomes with big data analytics. We isolated postsynaptic density95 (PSD-95) complexes from four human brain regions and compared their protein interactomes using multiple bioinformatics techniques. We demonstrate that human brain regions have unique postsynaptic protein signatures that may be used to interrogate perturbagen databases. Assessment of our hippocampal signature using the iLINCS database yielded several compounds with recently characterized off target effects on protein-protein interactions in the posynaptic density compartment. Copy rights belong to original authors. Visit the link for more info