Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.04.187518v1?rss=1 Authors: Pastor-Bernier, A., Stasiak, A., Schultz, W. Abstract: Reward-specific satiety changes the subjective value of one reward relative to other rewards. Two-dimensional indifference curves (IC) capture relative reward-specific values of two-component choice options according to Revealed Preference Theory. Any change of reward value would be captured by specific IC distortions. We estimated two-dimensional ICs from stochastic choice and found that natural on-going consumption of two liquid rewards led to characteristic IC changes indicative of relative value reduction of specific rewards, suggesting reward-specific satiety. Licking changes confirmed the satiety in a mechanism-independent manner. Neuronal reward signals in monkey orbitofrontal cortex (OFC) followed the specific IC distortions and indicated value changes compatible with relative reward-specific satiety. A neuronal classifier predicted well the value changes inferred from the altered behavioral choices. These results demonstrate that neuronal signals in OFC reflect the altered subjective value of selectively sated rewards during economic choice. Copy rights belong to original authors. Visit the link for more info