Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.03.132928v1?rss=1 Authors: Nishida, S., Matsumoto, Y., Yoshikawa, N., Son, S., Murakami, A., Hayashi, R., Nishimoto, S., Takahashi, H. Abstract: Schizophrenia patients often manifest semantic processing deficits. It has been proposed that these deficits stem from disorganized semantic representations in the brain. However, no study has yet examined the neural correlates of semantic disorganization by directly evaluating semantic representations in the brain. We used voxelwise modeling on functional magnetic resonance imaging signals to evaluate the semantic representations associated with several thousand words in individual patient brains. We then compared the structural properties of semantic representations to those in healthy controls. The variability of semantic representations was smaller both within individual patients and across patients compared to controls. Surrogate data analysis suggests that the observed reduction in representational variability is associated with disorganization of categorical information. To our knowledge, these findings provide the first evidence for sematic disorganization in schizophrenia at the level of brain representations. Copy rights belong to original authors. Visit the link for more info