Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.14.202853v1?rss=1 Authors: Wen, H., Eckenstein, K., Weihrauch, V., Stigloher, C., Brehm, P. Abstract: The escape response and rhythmic swimming in zebrafish are distinct behaviors mediated by two functionally distinct motoneuron (Mn) types. The primary (1{ring}Mn) type depresses, has a large quantal content (Qc), and a high release probability (Pr). Conversely, the secondary (2{ring}Mn) type facilitates and has low and variable Qc and Pr. This functional duality matches well the distinct associated behaviors, with the 1{ring}Mn providing the strong, singular C-bend initiating escape and the 2{ring}Mn confers weaker, rhythmic contractions. Contributing to these functional distinctions is our identification of P/Q type calcium channels mediating transmitter release in 1{ring}Mns and N type channels in 2{ring}Mns. Remarkably, despite these functional and behavioral distinctions, all ~15 individual synapses on each muscle cell are shared by a 1{ring}Mn bouton and at least one 2{ring}Mn bouton. This novel blueprint of synaptic sharing provides an efficient way of controlling two different behaviors at the level of a single postsynaptic cell. Copy rights belong to original authors. Visit the link for more info