Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.23.156018v1?rss=1 Authors: Stujenske, J. M., O'Neill, P.-K., Nahmoud, I., Goldberg, S., Diaz, L., Labkovich, M., Hardin, W., Bolkan, S. S., Reardon, T. R., Spellman, T. J., Salzman, C. D., Gordon, J. A., Likhtik, E. Abstract: The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate to discriminate a non-threatening stimulus is unknown. Here, we show that somatostatin interneurons (SOM) in the basolateral amygdala (BLA) activate specifically during learned non-threatening cues and block sensory-evoked phase resetting of theta-oscillations. SOM activation is PL-dependent, and prevents generalization. Thus, fear discrimination engages PL-dependent coordination of BLA responses to non-threatening stimuli. Copy rights belong to original authors. Visit the link for more info