Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.18.304261v1?rss=1 Authors: Loreto, A., Angeletti, C., Gilley, J., Arthur-Farraj, P., Merlini, E., Amici, A., Desrochers, L. M., Wang, Q., Orsomando, G., Coleman, M. P. Abstract: SARM1 is intensively studied for its role in promoting axon degeneration in injury and disease. We identify VMN, a metabolite of the neurotoxin vacor, as a potent SARM1 activator, an action likely to underlie vacor neurotoxicity in humans. This study provides novel tools to study SARM1 regulation, supports drug discovery, further links programmed axon death to human disease and identifies a new model where axons are permanently rescued. Copy rights belong to original authors. Visit the link for more info