Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.14.202317v1?rss=1 Authors: Marinaro, F., Haneklaus, M., Zhang, Z., Strano, A., Evans, L. D., Handfield, L.-F., Ryan, N., Fox, N., Hemberg, M., Ramanathan, S., Livesey, F. J. Abstract: Cell and molecular biology analyses of sporadic Alzheimer's disease brain are confounded by clinical variability, ageing and genetic heterogeneity. Therefore, we used single-nucleus RNA sequencing to characterize cell composition and gene expression in the cerebral cortex in early-onset, monogenic Alzheimer's disease. Constructing a cellular atlas of frontal cortex from 8 monogenic AD individuals and 8 matched controls, provided insights into which neurons degenerate in AD and responses of different cell types to AD at the cellular and systems level. Such responses are a combination of positively adaptive and deleterious changes, including large-scale changes in synaptic transmission and marked metabolic reprogramming in neurons. The nature and scale of the transcriptional changes in AD emphasizes the global impact of the disease across all brain cell types. Copy rights belong to original authors. Visit the link for more info