Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.15.153254v1?rss=1 Authors: Dong, D., Guell, X., Genon, S., Wang, Y., Chen, J., Eickhoff, S. B., Luo, C., Yao, D. Abstract: Objective: There is ample evidence for high co-morbidity and substantial overlap across psychiatric disorders, encouraging a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience and psychopathology. Converging evidence suggests that the cerebellum is involved in a wide range of cognitive functions and mental disorders. The authors examined the extent to which cerebellar function can be linked to transdiagnostic dimensions of psychopathology. Methods: The authors used a multivariate data-driven statistical technique (partial least squares) to identify latent dimensions linking human cerebellar connectome as assessed by functional MRI to a large set of clinical, cognitive, and trait measures in a sample of 198 participants, including healthy controls (n=92) as well as patients diagnosed with attention-deficit/hyperactivity disorder (n=35), bipolar disorder (n=36), and schizophrenia (n=35). Macroscale spatial gradients of connectivity at voxel level were used to characterize cerebellar connectome properties, which provide a low-dimensional representation of cerebellar connectivity, i.e., a sensorimotor-supramodal hierarchical organization. Results: This multivariate analysis revealed significant correlated patterns of cerebellar connectivity gradients and behavioral measures that could be represented into four latent dimensions. Each dimension was associated with a unique spatial pattern of cerebellar connectivity gradients across all participants, and linked to different clusters of behavioral measures including clinical, cognitive, and personality scores. Multiple control analyses and 10-fold cross-validation confirmed the robustness and generalizability of the yielded four dimensions. Conclusions: The robust associations between cerebellar functional gradients and multiple transdiagnostic behavioral dimensions of psychopathology highlight the importance of cerebellar function in transdiagnostic behavioral dimensions of psychopathology. Copy rights belong to original authors. Visit the link for more info