Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.26.116475v1?rss=1 Authors: Wang, L., Lin, F. V., Cole, M., Zhang, Z. Abstract: Structural brain networks constructed from diffusion MRI are important biomarkers for understanding human brain and its relation to cognitive functioning. There is increasing interest in learning differences in structural brain networks between groups of subjects in neuroimaging studies, leading to a variable selection problem in network classification. Traditional methods often use independent edgewise tests or unstructured generalized linear model (GLM) with regularization on vectorized networks to select edges distinguishing the groups, which ignore the network structure and make the results hard to interpret. In this paper, we develop a symmetric bilinear logistic regression (SBLR) with elastic-net penalty to identify a set of small clique subgraphs in network classification. Clique subgraphs, consisting of all the interconnections among a subset of brain regions, have appealing neurological interpretations as they may correspond to some anatomical circuits in the brain related to the outcome. We apply this method to study the differences in structural connectome between adolescents with high and low crystallized cognitive ability, using the crystallized cognition composite score and picture vocabulary and oral reading recognition tests from NIH Toolbox. A few clique subgraphs containing several small sets of brain regions are identified between different levels of functioning, indicating their importance in crystallized cognition. Copy rights belong to original authors. Visit the link for more info