Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.21.053579v1?rss=1 Authors: Sjogard, M., Bourguignon, M., Costers, L., Dumitrescu, A., Coolen, T., Roshchupkina, L., Destoky, F., Bertels, J., Niesen, M., Vander Ghinst, M., Van Schependom, J., Nagels, G., Urbain, C., Peigneux, P., Goldman, S., Woolrich, M. W., De Tiege, X., Wens, V. Abstract: Human brain activity is not merely responsive to environmental context but includes intrinsic dynamics, as suggested by the discovery of functionally meaningful neural networks at rest, i.e., even without explicit engagement of the corresponding function. Yet, the neurophysiological coupling mechanisms distinguishing intrinsic (i.e., task-invariant) from extrinsic (i.e., task-dependent) brain networks remain indeterminate. Here, we investigated functional brain integration using magnetoencephalography throughout rest and various tasks recruiting different functional systems and modulating perceptual/cognitive loads. We demonstrated that two distinct modes of neural communication continually operate in parallel: extrinsic coupling supported by phase synchronization and intrinsic integration encoded in amplitude correlation. Intrinsic integration also contributes to phase synchronization, especially over short (second-long) timescales, through modulatory effects of amplitude correlation. Our study establishes the foundations of a novel conceptual framework for human brain function that fundamentally relies on electrophysiological features of functional integration. This framework blurs the boundary between resting-state and task-related neuroimaging. Copy rights belong to original authors. Visit the link for more info