Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.16.342360v1?rss=1 Authors: Kumar, N., Jaiswal, A. K., Roy, D., Banerjee, A. Abstract: Structure-function relationships are of fundamental importance to biological systems. In the human auditory system, it has been demonstrated that asymmetric neuroanatomic embedding of primary auditory cortices in the whole brain network is predictive of functional lateralisation. However, a mechanistic and causal basis of the functional asymmetry due to the underlying structural constraints is poorly understood. The present article takes the help of computational modelling to demonstrate how functional lateralization emerges from the symmetries in structural connectome. First, we demonstrate a well-known lateralisation effect observed during entrainment of external rhythmic auditory stimulus at the level of cortical sources from EEG data. Subsequently, we simulate the dynamics of whole brain cortical responses from large-scale neurodynamic model using realistic connection topologies. Considering the effects of time-delay stemming from physical fibre distances computed from diffusion imaging metrics, and neuronal scaling and coupling based on empirical data, we could elucidate the biophysically realistic parameter regimes where the structural connectome is predictive of functional lateralisation. Thus our study provides a roadmap in causally linking structural symmetries to higher order brain function. Copy rights belong to original authors. Visit the link for more info