Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.27.356592v1?rss=1 Authors: BELUR NAGARAJ, S., kahali, p., Purdon, P. L., Shapiro, F., Westover, B. Abstract: Objective: Electroencephalogram (EEG) monitors are often used to monitor depth of general anesthesia. EEG monitoring is less well developed for lighter levels of anesthesia. Here we present an automated method to monitor the depth of anesthesia for office based procedures using EEG spectral features. Methods: We analyze EEG recordings from 30 patients undergoing sedation using a multimodal anesthesia strategy. Level of sedation during the procedure is coded using the Richmond Agitation and Sedation Scale (RASS). The power spectrum from the frontal EEG is used to infer the level of sedation, by training a logistic regression model with elastic net regularization. Area under the receiver operator characteristic curve (AUC) is used to evaluate how well the automated system distinguishes awake from sedated EEG epochs. Results: EEG power spectral characteristics vary systematically and consistently across patients with the levels of light anesthesia and relatively healthy patients encountered during office-based anesthesia procedures. The logistic regression model using spectral EEG features distinguishes awake and sedated states with an AUC of 0.85 ( 0.14). Conclusions: Our results demonstrate that frontal EEG spectral features can reliably monitor sedation levels during office based anesthesia. Copy rights belong to original authors. Visit the link for more info