Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.07.356311v1?rss=1 Authors: Shen, S., Wang, Y., Xia, R., Zeng, F., Cao, J., Liu, X., Zhang, Y., Wang, Z., Tao, T. Abstract: The cell type-specific molecular pathology of post-stroke cognitive impairment (PSCI) in the hippocampus has not been thoroughly elucidated. We analyzed 27,069 cells by using single-cell RNA sequencing, and four oligodendrocyte precursor cell (OPC) subtypes were identified, Vcan+ OPCs, which were determined to be the primary cluster among them. Additionally, we examined the features of endothelial cells (ECs) and found that Lcn2+ ECs might play neuroprotective roles via Vwf after stroke. These results may facilitate further studies attempting to identify new avenues of research and novel targets for PSCI treatment. Copy rights belong to original authors. Visit the link for more info