Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.15.152991v1?rss=1 Authors: Schoenbaum, G., Hart, E., Gardner, M., Sharpe, M. Abstract: The orbitofrontal cortex (OFC) is necessary for value inference in tests of model-based reasoning. This ability could be accounted for by either representation of value or by representation of broader associative structure. Our lab recently reported correlates of both value and of valueless associative structure in OFC using single-unit recording (Sadacca et al., 2018). This incidental stimulus-stimulus representation was surprising since OFC was thought to be involved only when items of biological significance were driving responses. However, we did not assess whether this activity was necessary for encoding the associative information that would contribute to value inference during probe testing. Here, we used optogenetic OFC inhibition during sensory preconditioning to test this. We found that OFC inhibition during preconditioning impaired value inference during the probe test, demonstrating that the correlates we previously observed are not simply downstream readouts of sensory processing and instead contribute to encoding valueless sensory associative information. Copy rights belong to original authors. Visit the link for more info