Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.19.104497v1?rss=1 Authors: Ruiz, N. A., Thieu, M., Aly, M. Abstract: Attention to the relations between visual features modulates hippocampal representations. Moreover, hippocampal damage impairs discrimination of spatial relations. We explore a mechanism by which this might occur: modulation by the acetylcholine system. Acetylcholine enhances afferent input to the hippocampus and suppresses recurrent connections within it. This biases hippocampal processing toward environmental input, and should improve externally-oriented, hippocampally mediated attention and perception. We examined cholinergic modulation on an attention task that recruits the hippocampus. On each trial, participants viewed two images (rooms with paintings). On 'similar room' trials, they judged whether the rooms had the same spatial layout from a different perspective. On 'similar art' trials, they judged whether the paintings could have been painted by the same artist. On 'identical' trials, participants simply had to detect identical paintings or rooms. We predicted that cholinergic modulation would improve performance on the similar room task, given past findings that hippocampal representations predicted, and hippocampal damage impaired, behavior on this task. To test this, nicotine cigarette smokers took part in two sessions: one before which they abstained from nicotine for 12 hours, and one before which they ingested nicotine in the past hour. Individual differences in expired breath carbon monoxide levels - a measure of how recently or how much someone smoked - predicted performance improvements on the similar room task. This finding provides novel support for computational models that propose that acetylcholine enhances externally oriented attentional states in the hippocampus. Copy rights belong to original authors. Visit the link for more info