Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.10.145003v1?rss=1 Authors: Abou-Fadel, J., Jiang, X., Padarti, A., Goswami, D., Smith, M., Grajeda, B., Walker, W., Zhang, J. Abstract: We demonstrate that a novel signaling network among the CSC and mPRS is dynamically modulated and fine-tuned with intricate feedback regulations in PR negative cells, especially endothelial cells (ECs). Depletion of any of three CCMs (1, 2, 3) genes results in the disruption of non-classic mPRs -mediated signaling in-vitro as well as defective homeostasis of PRG in-vivo. Therefore, we propose the CSC is a master regulator of homeostasis of PRG and its associated classic and non-classic signaling cascades. Assisted with omic approaches, we identified signaling pathways involved and specific biomarkers associated with hemorrhagic events during CCM pathogenesis in-vitro and in-vivo. To our knowledge, this is the first report detailing etiology to predict the occurrence of early hemorrhagic events with a set of serum biomarkers. Copy rights belong to original authors. Visit the link for more info