Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.05.370031v1?rss=1 Authors: Escoubas, C. C., Laversenne, V., Tabakovic, E., Weir, H. J., Clark, N., Mair, W. B. Abstract: Loss of metabolic homeostasis is one of the hallmarks of the aging process that might contribute to pathogenesis by creating a permissive landscape over which neurodegenerative diseases can take hold. AMPK, a conserved energy sensor, extends lifespan and is protective in some neurodegenerative models. AMPK regulates mitochondrial homeostasis and morphology, however, whether mitochondrial regulation causally links AMPK to protection against loss of neuronal function with aging and diseases remains unclear. Here we use an associative learning protocol in C. elegans as a readout of neuronal function and show that AMPK activation enhances associative learning and prevents age-related loss of learning capacity. AMPK promotes neuronal mitochondrial fusion and driving mitochondrial fragmentation via fzo-1 deletion blocks AMPK's effects on associative learning. Restoring mitochondrial fusion capacity specifically in the neurons rescues learning capacity downstream of AMPK. Finally, AMPK activation rescues neuronal A{beta}42 induced loss of associative learning. Overall, our results suggest that targeting neuronal metabolic flexibility may be a viable therapeutic option to restore neuronal function in the context of aging and neurodegenerative diseases. Copy rights belong to original authors. Visit the link for more info