Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.15.097972v1?rss=1 Authors: Badrinarayanan, S., Manseau, F., Lim, B. K., Williams, S., Brandon, M. P. Abstract: Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their activation. Cortical Vasoactive Intestinal Peptide (VIP) expressing inhibitory neurons predominantly contact interneurons, providing a local disinhibitory mechanism. Here, we investigate the electrophysiological and morphological properties of VIP cells using in vitro whole-cell patch clamp recordings and use rabies-mediated circuit tracing to discover long-range inputs that may modulate this population in mice. We report physiological and morphological properties of VIP cells that differ across lamina and along the dorsal-ventral MEC axis. Furthermore, we reveal long-range inputs to VIP neurons from regions known to encode proprioceptive and auditory information, including the mesencephalic trigeminal nucleus and superior para-olivary nuclei, respectively. These results characterize the properties of VIP cells and reveal sensory modalities that could drive disinhibition in the MEC. Copy rights belong to original authors. Visit the link for more info