Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.10.145110v1?rss=1 Authors: Somayaji, M., Cataldi, S., Edwards, R. H., Mosharov, E. V., Sulzer, D. Abstract: -Synuclein is expressed at high levels at presynaptic terminals, but defining its role on neurotransmission under physiologically-relevant conditions has proven elusive. We report that -synuclein is responsible for a rapid facilitation of dopamine release during action potential bursts in vivo. This occurs in tandem with a far slower stimulus-dependent depression, appears to be independent of the presence of {beta}- and {gamma}-synucleins or effects on presynaptic calcium and is consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. The results indicate that the presynaptic effects of -synuclein are dependent on specific patterns of neuronal activity. Copy rights belong to original authors. Visit the link for more info