In the second installment of this ongoing series covering wet AMD, Lisa Faia, MD, and Sumit Sharma, MD, submit to host John Kitchens, MD, a set of real-world patient cases in which treatment challenges necessitated a change in therapy. After revealing which treatment option is best suited for their respective patients, Drs. Faia and Sharma parse which patient types are eligible for long-duration treatment and which types are better matched for more traditional approaches.\xa0\nThis editorially independent podcast is supported with advertising.