In this show, we had the pleasure of speaking with Steve Henikoff who studies chromosomes, chromatin dynamics and epigenetics and develops genomics and computational tools to facilitate this research. He received a BS from the University of Chicago and a PhD from Harvard University and did post-doctoral work at the University of Washington. He has been a faculty member of the Fred Hutchinson Cancer Research Center since 1981. He is also an investigator of the Howard Hughes Medical Institute, an affiliate professor of Genome Sciences at the University of Washington, a member of the National Academy of Sciences and co-Editor-in-Chief of the open access journal Epigenetics & Chromatin. In this episode we’re talking with Steve about his work, his approach to method development and refinement, and more. Links: Steven Henikoff protocols.io publications - https://www.protocols.io/researchers/steven-henikoff/protocols Human Cell Atlas - https://www.humancellatlas.org/ CUT&Tag@home was recently chosen by the The Scientist as one of the top 5 technical advances of 2020 - https://www.the-scientist.com/news-opinion/top-technical-advances-of-2020-68297 CUT&Tag@home - https://dx.doi.org/10.17504/protocols.io.bmbfk2jn eLife article ‘Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation‘ - https://doi.org/10.7554/eLife.63274 Jim Watson’s book “Molecular Biology of the Gene” - https://www.amazon.com/Molecular-Biology-Fifth-James-Watson/dp/080534635X NIH ENCODE Project - https://www.genome.gov/Funded-Programs-Projects/ENCODE-Project-ENCyclopedia-Of-DNA-Elements