Dexamethasone and High-Dose Methotrexate in High-Risk B Cell Acute Lymphoblastic LeukemiaWhere Should We Go From Here?
The Children's Oncology Group study led by Larsen et al. showed that children and young adult patients with high-risk B cell acute lymphoblastic leukemia benefit from receiving high-dose methotrexate during interim maintenance 1 and that those aged 1 to 9 years benefit from receiving dexamethasone for 14 days during induction.