A comprehensive review article in the April issue of Gastroenterology looks at the role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis, including pathophysiology, clinical implications, and future directions. Dr. Kuemmerle speaks to author Dr. Kenneth Cusi of the University of Florida College of Medicine; Plus, a rundown of top stories from this month's issue of GI and Hepatology News.