For severe, acute pain, 1000 mg of acetaminophen PLUS 400 mg of ibuprofen is as effective as acetaminophen/oxycodone, acetaminophen/hydrocodone, or acetaminophen/codeine.\xa0Listen to this week\u2019s episode to learn more about treating acute pain safely.\xa0 \xa0 Learning Objectives:\xa0 Review the current trial comparing Acetaminophen plus Ibuprofen to other acetaminophen/opioid combinations on pain outcomes Summarize the other data supporting this combination in children and adults Understand the path that can lead from acute pain to dependence.