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I am delighted to reconnect with Dr. Anurag Singh today, the Chief Medical Officer at Timeline Nutrition. He joined me once before on Episode 268.\xa0\nI invited Dr. Singh back to discuss the latest research on GLP-1 agonists like Wegovy, Semaglutide, and Ozempic, which are gaining significant traction with projected sales exceeding $100 billion by 2030, potentially affecting 9% of the US population.\nIn our conversation, we explore the contributors to our metabolic health crisis by looking at the research surrounding GLP-1 agonists, the physiology of GLP-1 peptides, and the influencing elements Dr. Singh refers to as the trifecta. We dive into the loss of muscle mass and strength, sarcopenia, and frailty associated with these drugs, and Dr. Singh shares his concerns about their impact on bone health, the gut microbiome, and their use in younger patients. We also get into lifestyle measures, mitochondrial health, hallmarks of aging, Akkermansia, and the importance of advocacy and patient empowerment.\xa0\nToday\u2019s compelling and invaluable discussion with Dr. Anurag Singh highlights crucial insights into GLP-1 agonists and their broader health implications. I know it will provide significant value for our listeners.\n\nIN THIS EPISODE YOU WILL LEARN:\n\nDr. Singh breaks down what GLP-1 agonist drugs are and how they work.\n\nHow our modern-day lifestyles contribute to poor metabolic health\n\nThe benefits and side-effects of using GLP-1 agonist treatments for improving metabolic health\n\nWhy strength training is essential for preventing muscle loss and frailty in middle-aged women\n\nWhat are the potential long-term effects of SARMs on muscle mass and health?\n\nWhy dietary counseling is essential for those taking GLP-1 agonist drugs\n\nThe benefits of supplements for boosting mitochondrial health\xa0\n\nDr. Singh discusses a research study on combining lithium with GLP-1 agonists to improve the muscle quality of those with muscle-wasting conditions.\n\nWhy akkermansia is essential for GLP production\n\n\xa0\nConnect with Cynthia Thurlow\xa0\xa0\n\nFollow on Twitter\n\n\nInstagram\n\nLinkedIn\n\nCheck out Cynthia\u2019s website\xa0\n\nSubmit your questions to support@cynthiathurlow.com\n\n\n\nConnect with Dr. Anurag Singh\n\nTimeline\n\nMitopure\n\nEmail Dr. Singh: asingh@amazentis.com\xa0\n\n\n\nPrevious Episode Mentioned\nEp. 268: Understanding the Biology of Aging with Evolved Supplementation and Nutrition, featuring Dr. Anurag Singh