Researching Sanfilippo syndrome
In this weeks Dementia Researcher Podcast, we hear from Dr Karissa Barthelson, one of the latest Race Against Dementia Research Fellows from Flinders University \u2013 discussing her research, and specifically an introduction to Sanfilippo syndrome, a rare form of childhood dementia, and her research on this disease.\n\nRegular Dementia Researcher Bloggers Dr Anna Volkmer & Dr Kamar Ameen-Ali lead the interview, helping us to understand Karissa\u2019s work and exploring the science.\n\nAll types of neurodegenerative diseases share common molecular mechanisms responsible for disease etiology and progression. Karissa, is interested in understanding these shared mechanisms, as targeting the common problems could lead to new therapeutics to benefit more individuals who live with these diseases. To understand the shared molecular mechanisms, Karissa utilises zebra fish, as a model organism. Introducing mutations into zebrafish, equivalent to those which cause neurodegenerative diseases in humans (e.g., Alzheimer's disease, Sanfilippo syndrome childhood dementia), then analysing their brains with very high molecular detail.\n\nFor more information about Sanfilippo syndrome visit: \n\nhttps://en.wikipedia.org/wiki/Sanfilippo_syndrome \n\nFor more information on Race Against Dementia visit:\n\nhttps://www.raceagainstdementia.com\n\nYou can find out more about our panellists, and their work on our website. There you will also find a full transcript:\n\nhttps://www.dementiaresearcher.nihr.ac.uk/podcast-researching-sanfilippo-syndrome/ \n\n--\n\nLike what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode.\n\nThis podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.