A longitudinal research study of familial Alzheimers disease
Megan O'Hare talks to Ivanna Pavisic and Antoinette O\u2019Connor about their different projects relating to \u2018Longitudinal research study of familial Alzheimer\u2019s disease' and the changes that occur at this clinically silent stage.\n\nIvanna and Antoinette both work at the University College London, Dementia Research Centre which has had a longstanding research programme in autosomal dominantly inherited familial Alzheimer\u2019s disease (FAD) led by Professor Nick Fox.\n\nIn this podcast they talk about how the study provides a unique opportunity to explore the presymptomatic period of AD as pathogenic mutations are effectively 100% penetrant and the age at onset is relatively consistent within families and they also talk about the use and need for reliable biomarkers and cognitive tests.\n\nYou can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk\n\nPlease take a moment to review, like and share our podcast - and don't forget to subscribe to ensure you never miss an episode.