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#048This week, Melissa and Jam dive into spiciness. What is it? Is it a flavor? Is it a feeling? Is it both? Is it more? Why can some people handle more than others? Does spiciness have any benefits?We're proud to partner with MEL Science. Check out their home chemistry experiment sets here: bit.ly/melchemReferences from this episode\nhttps://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/vanilloids\nSolomon\u2019s Organic Chemistry 11th edition\nAnalogues of Capsaicin with Agonist Activity as Novel Analgesic agents; Structure-Activity Studies 2. The Amide Bond \u201cB-Reigion\u201d byWalpole et. al\nSimilarities and Differences in the Structure\u2212Activity Relationships of Capsaicin and Resiniferatoxin Analogues by Walpole et. al\nDetailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study by Ohbuchi et. al\nThe Art and Science of Organic andNatural Products Synthesis - by Nicolau et. al\n\nhttps://www.acs.org/content/acs/en/pressroom/reactions/videos/2015/why-are-hot-peppers-hot-and-how-milk-helps.html\n\nFind us on Instagram, Twitter, and Facebook @ChemForYourLife.Email us at chemforyourlife@gmail.comAnd check out our chill, simple little website at https://chemforyourlife.transistor.fm/\nThanks to our monthly supporters\n\n Ciara Linville\n J0HNTR0Y\n Jeannette Napoleon\n Cullyn R\n Erica Bee\n Elizabeth P\n Sarah Moar\n Rachel Reina\n Letila\n Katrina Barnum-Huckins\n Suzanne Phillips\n Nelly Silva\n Venus Rebholz\n Lyn Stubblefield\n Jacob Taber\n Brian Kimball\n Emerson Woodhall\n Kristina Gotfredsen\n Timothy Parker\n Steven Boyles\n Chris Skupien\n Chelsea B\n Bri McAllister\n Avishai Barnoy\n Hunter Reardon\n\n\n \u2605 Support this podcast on Patreon \u2605