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The following question refers to Section 6.1 of the\xa02021 ESC CV Prevention Guidelines. The question is asked by\xa0Dr. Christian Faaborg-Andersen, answered first by\xa0UCSD\xa0cardiology fellow\xa0Dr. Harpreet Bhatia,\xa0and then by expert faculty\xa0Dr. Eugenia Gianos.\nDr. Gianos specializes in preventive cardiology, lipidology, cardiovascular imaging, and women\u2019s heart disease; she is the director of the Women\u2019s Heart Program at Lenox Hill Hospital and director of Cardiovascular Prevention for\xa0Northwell Health.\nThe CardioNerds Decipher The Guidelines Series for the 2021 ESC CV Prevention Guidelines\xa0represents a collaboration with the\xa0ACC Prevention of CVD Section, the\xa0National Lipid Association, and\xa0Preventive Cardiovascular Nurses Association.\t\t\n\t\t\t\t\t\t\t\t\t\t\t\tQuestion #11\n\t\t\t\t\tA 70-year-old man with a history of hypertension, diabetes, hyperlipidemia, peptic ulcer disease with a prior upper GI bleed, as well as coronary artery disease presents to clinic. About one year ago he suffered an NSTEMI treated with percutaneous coronary intervention to the mid LAD. He is feeling well and able to walk 1 mile daily with no anginal symptoms. He is currently taking aspirin 81 mg daily, ticagrelor 90 mg BID, atorvastatin 40 mg daily, metoprolol 25 mg BID, lisinopril 5 mg daily, and lansoprazole 15mg daily. He has a preserved ejection fraction. His BP in clinic is 110/70 and HR is 65 bpm. His LDL is 50 mg/dL. What do you recommend for his further management?\nA. Switch ticagrelor to clopidogrel, continue indefinitelyB. Stop ticagrelor, continue aspirin indefinitelyC. Continue aspirin + ticagrelor indefinitelyD. Stop ticagrelor, start rivaroxaban 2.5 mg BIDListen to the podcast episode!\n\t\t\t\t\t\t\t\t\t\t\t\tAnswer #11\n\t\t\t\t\tThe correct answer is B\xa0\u2013 stop ticagrelor, continue aspirin indefinitely.Twelve months of DAPT is recommended for acute coronary syndromes (Class I, LOE A). Long-term secondary prevention with dual anti-thrombotic therapy (DAPT > 12 months with a P2Y12 inhibitor and low-dose aspirin or low-dose rivaroxaban 2.5mg BID with low-dose aspirin) may be considered for patients who are at high ischemic risk without high risk of bleeding (Class IIa, LOE A). However, this patient is at increased bleeding risk (peptic ulcer disease with prior GI bleeding) and has no ischemic symptoms, and so neither would be recommended.Main TakeawayIn summary, 12 months of DAPT is recommended after ACS. Prolonged DAPT or low-dose rivaroxaban may be considered with high ischemic risk and low bleeding risk.Guideline LocationSection 6.1, Pages 3294-3295.\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\tCardioNerds Decipher the Guidelines - 2021 ESC Prevention SeriesCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor RollCardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron!