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CardioNerds\xa0(Amit Goyal\xa0and\xa0Daniel Ambinder), join CardioNerds FIT Ambassador, Dr. Natasha Cuk and her co-fellows, Dr. Lily Stern, and Dr. Paul Marano from the Cedars-Sinai Cardiology Fellowship for some late afternoon smoothies on the beach. They discuss the case of a 46-year-old woman who presented with sudden cardiac arrest and was ultimately found to have a mobile intraluminal aortic thrombus adherent to a penetrating ulcer in the ascending aorta. This mobile thrombus was ultimately thought to be the cause of transient ischemia and the patient\u2019s cardiac arrest. We discuss a differential for sudden cardiac arrest, initial management after resuscitated cardiac arrest, a differential for arterial thrombus, and review an illness script for penetrating atherosclerotic ulcers. Dr. Dominick Megna provides the provides the\xa0E-CPR\xa0for this episode.\xa0Audio editing by\xa0Dr. Gurleen Kaur\xa0(Director of the CardioNerds Internship).\n\n\n\nThis Case Report has been published in JACC Case Reports!\n\n\n\nClaim free CME just for enjoying this episode!\xa0\n\n\n\nDisclosures: NoneJump to: Pearls - Notes - References \n\n\n\n\n\n\n\n\n\nCardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll\n\n\n\n\n\nCardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron!\n\n\n\n\n\n\n\n\n\nEpisode Teaching\n\n\n\n\nhttps://twitter.com/LilySternMD/status/1460811173113184263?s=20\n\n\n\n\nPearls - Cardiac Arrest due to Aortic Thrombus\n\n\n\nAfter cardiac arrest, the initial ECG obtained after the return of spontaneous circulation can provide important information on the etiology of the arrest. The ECG can narrow our structured differential, for which one approach would be the following breakdown: acute ischemic events, structural heart disease, arrhythmogenic syndromes with no structural abnormality, and then non-cardiac causes such as drugs, toxins, trauma, metabolic arrangementsThe risk vs benefit of emergent angiography after sudden cardiac arrest depends on balancing the potential benefit from revascularization in an acute ischemic event vs bleeding risks and potential delays in other aspects of care, particularly given that a large percentage of mortality is related to neurologic injury from the arrest, which would not be impacted by immediate angiography. The available randomized controlled trial evidence has not demonstrated a survival or neurologic outcome benefit to immediate angiography, and the decision depends on weighing the risk/benefit for each patient.Due to high flow, a thrombus in the aorta should prompt an investigation for causes focused on the other two \u2018points\u2019 of Virchow\u2019s triad (aside from stasis): endothelial injury and hypercoagulability.A penetrating atherosclerotic ulcer (PAU) is a deep atherosclerotic lesion where there is a focal ulceration of the elastic lamina that extends through the medial layer of the aortic wall. These lesions are most commonly associated with extensive atherosclerosis, but can also occur related to inflammatory, infectious, or traumatic causes.A PAU is a type of acute aortic syndrome and accounts for up to 8% of total acute aortic syndromes. It may present with a spectrum of symptoms, including as an incidental finding on cardiothoracic imaging or a severe chest and back pain, like an aortic dissection. While it is a subtype of aortic syndrome, PAU can also progress to become aortic dissection and rupture.\n\n\n\nNotes - Cardiac Arrest due to Aortic Thrombus\n\n\n\n1. How might a post-ROSC ECG help determine the etiology of a sudden cardiac arrest?\n\n\n\nDuring our case, we discussed a systematic approach to the differential diagnosis for sudden cardiac arrest. We broke down the causes into the buckets of:\n\n\n\nAcute ischemic eventsStructural heart diseaseArrhythmogenic syndromes with no structural heart diseaseNon-cardiac causes such as drugs, toxins, trauma, and metabolic arrangements\n\n\n\nThe post-ROSC ECG can provide immediate information to help narrow our diffe...