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Yale School of Medicine physician and researcher F. Perry Wilson, MD, MSCE, chats with Trey Elling about HOW MEDICINE WORKS AND WHEN IT DOESN\u2019T: LEARNING WHO TO TRUST TO GET AND STAY HEALTHY. Topics include:

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• Goal with the book (0:00)
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• Pharma\u2019s role with patient mistrust (1:57)
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• Pharma\u2019s influence on doctors (6:49)
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• Generic drugs not such an easy fix (10:22)
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• How medical errors commonly lead to death (12:34)
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• Surrogate outcomes (15:50)
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• Getting patients to change their minds for GOOD reasons (17:44)
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• Combatting motivated reasoning (20:44)
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• The \u201cbiggest secret in medicine\u201d (26:22)
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• Factoring in side effects when considering a drug (29:32)
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• Doctors\u2019 responsibility to help patients with despair (31:28)
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• Randomized controlled trials, aka RCTs (37:48)
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• How RCTs go wrong (44:19)
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• The difficulty with replication (47:29)
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• Why \u201copen data\u201d isn\u2019t already the standard with RCTs (50:35)
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• The problem with the \u201cmiddle man\u201d in patient care (53:39)
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• An alternative to the current US healthcare system (57:06)
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• How patients can move closer to doctors by embracing uncertainty (1:00:15)
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