Summary of the January 1, 2013 issue, including articles on distributing naloxone to heroin users, HIV acquisition among U.S. women, influenza vaccine in HIV-infected persons, the association between health care quality and cost, adverse effects of transcatheter aortic valve implantation, use of performance measures to decrease low-value services, and episode-based bundled payments, as well as the USPSTF recommendation statement on menopausal hormone therapy to prevent of chronic conditions and a commentary on the "overdiagnosis" of breast cancer.